Home Chemistry Organic Building Blocks Difluoromethyls 1-(Difluoromethyl)-2-Fluorobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CHF2).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Reductive Reactions: The difluoromethyl group can potentially undergo reductive transformations to yield difluoromethylated products under appropriate conditions.
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1-Bromo-3-(difluoromethyl)-2-fluorobenzene
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4-(Difluoromethyl)-3-fluorobenzoic acid
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(R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethan-1-amine hydrochloride
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(R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethanamine
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(S)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethan-1-amine hydrochloride
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3-(Difluoromethyl)-4-fluoroaniline hydrochloride
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3-(Difluoromethyl)-4-fluorobenzoic acid
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2-(Difluoromethyl)-1-fluoro-4-nitrobenzene
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(4-(Difluoromethyl)-3,5-difluorophenyl)boronic acid
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5-Bromo-2-(difluoromethyl)-1,3-difluorobenzene
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4-Bromo-2-(difluoromethyl)-1-fluorobenzene
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