Home Chemistry Heterocyclic Building Blocks Oxadiazoles 2-Phenyl-1,3,4-Oxadiazole
Electrophilic Aromatic Substitution: The phenyl ring in the compound is susceptible to electrophilic aromatic substitution reactions, such as nitration, halogenation, or sulfonation.
Nucleophilic Substitution: The oxygen atom in the oxadiazole ring can act as a nucleophile in certain reactions. For instance, it can undergo nucleophilic substitution reactions with alkyl halides or acyl halides to form substituted oxadiazoles.
Nucleophilic Addition: The oxadiazole ring can undergo nucleophilic addition reactions with electrophiles, such as alkylating agents, leading to the formation of substituted products.
Ring Opening: The oxadiazole ring can potentially undergo ring-opening reactions under specific conditions, leading to the formation of different compounds.
Coupling Reactions: The phenyl group can participate in various coupling reactions, such as Suzuki, Heck, or Stille couplings, to introduce different substituents.
Cyclization: Depending on the reaction conditions and reagents, the compound can participate in intramolecular cyclization reactions, forming different cyclic structures.
Substitution Reactions: Substitution reactions can occur on the phenyl or oxadiazole rings to introduce various substituents, such as alkyl, aryl, or other functional groups.
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(3-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl)boronic acid
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(4-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl)boronic acid
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2-(Chloromethyl)-5-(3,4-dichlorophenyl)-1,3,4-oxadiazole
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2-(Chloromethyl)-5-phenyl-1,3,4-oxadiazole
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5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-amine
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5-(3-Fluorophenyl)-1,3,4-oxadiazol-2-amine
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Ethyl 5-(4-bromophenyl)-1,3,4-oxadiazole-2-carboxylate
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Ethyl 5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylate
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Ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate
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5-(2,4-Dichlorophenyl)-1,3,4-oxadiazole-2-thiol
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5-(4-Aminophenyl)-1,3,4-oxadiazole-2-thiol
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