Home Chemistry Organic Building Blocks Bromides 2-Bromo-1-Fluoro-4-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—NO2).
Grignard Reaction: Bromobenzene can react with a Grignard reagent (organomagnesium compound) to form a new carbon-carbon bond, leading to the introduction of various functional groups.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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1-Bromo-2-fluoro-4-methoxy-5-nitrobenzene
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Methyl 4-bromo-5-fluoro-2-nitrobenzoate
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1-Bromo-2-fluoro-5-nitro-3-(trifluoromethyl)benzene
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1-Bromo-2-fluoro-3-methyl-5-nitrobenzene
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