Chemistry Heterocyclic Building Blocks Tetrahydroisoquinolines 1,4-Dihydroisoquinolin-3(2H)-One

1,4-Dihydroisoquinolin-3(2H)-One

Reduction: The compound contains a carbonyl group, which is reducible. It can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). Acylation: The lactam nitrogen can act as a nucleophile and react with acyl halides or anhydrides to form an amide. For instance, reaction with an acid chloride would yield an N-acyl compound. Ring Opening Reactions: Depending on the conditions and reagents used, the lactam ring could potentially be opened, leading to different products. This could result in the formation of open-chain compounds. Alkylation or Arylation: The nitrogen atom in the lactam can be alkylated or arylated, introducing a substituent at this position. This can be achieved using appropriate alkyl or aryl halides and a suitable base. Cyclization Reactions: Depending on the structure of the starting material and the reagents used, further cyclization reactions can occur to form more complex polycyclic compounds. Oxidation: The secondary amine in the molecule can potentially be oxidized to form the corresponding imine or iminium ion. Hofmann Rearrangement: Under certain conditions, the lactam nitrogen could potentially undergo a Hofmann rearrangement, resulting in a rearranged amide. Dehydration: Depending on the conditions, the compound may undergo dehydration reactions to form unsaturated compounds.

Further Reading:

Framework+−

(9H-Fluoren-9-Yl)Methyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate 1,2,3,4-Tetrahydroisoquinolin-5-Amine 1,2,3,4-Tetrahydroisoquinolin-5-Ol 1,2,3,4-Tetrahydroisoquinolin-6-Amine 1,2,3,4-Tetrahydroisoquinolin-6-Ol 1,2,3,4-Tetrahydroisoquinolin-7-Amine 1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid 1,4-Dihydroisoquinolin-3(2H)-One 1-Methyl-1,2,3,4-Tetrahydroisoquinoline 2-Methyl-1,2,3,4-Tetrahydroisoquinoline 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline 5,6,7,8-Tetrahydroisoquinoline 5-Bromo-1,2,3,4-Tetrahydroisoquinoline 5-Chloro-1,2,3,4-Tetrahydroisoquinoline 5-Fluoro-1,2,3,4-Tetrahydroisoquinoline 5-Methyl-1,2,3,4-Tetrahydroisoquinoline 6-Bromo-1,2,3,4-Tetrahydroisoquinoline 6-Chloro-1,2,3,4-Tetrahydroisoquinoline 6-Fluoro-1,2,3,4-Tetrahydroisoquinoline 6-Methoxy-1,2,3,4-Tetrahydroisoquinoline 6-Nitro-1,2,3,4-Tetrahydroisoquinoline 7-Bromo-1,2,3,4-Tetrahydroisoquinoline 7-Chloro-1,2,3,4-Tetrahydroisoquinoline 7-Fluoro-1,2,3,4-Tetrahydroisoquinoline 7-Methoxy-1,2,3,4-Tetrahydroisoquinoline 7-Nitro-1,2,3,4-Tetrahydroisoquinoline Isoquinoline-1,3(2H,4H)-Dione

By Key Group+−

Hydroxy-Tetrahydroisoquinolin Methyl-Tetrahydroisoquinoline Other-Tetrahydroisoquinoline Phenyl-Tetrahydroisoquinoline Tetrahydroisoquinolin-Amine Tetrahydroisoquinoline-Bromide Tetrahydroisoquinoline-Carboxylate Tetrahydroisoquinoline-Carboxylic Acid Tetrahydroisoquinoline-Carboxylic-Acid Tetrahydroisoquinoline-Chloride Tetrahydroisoquinoline-Hydrochloride Tetrahydroisoquinoline-Methanol Tetrahydroisoquinoline-Nitro Trifluoromethyl-Tetrahydroisoquinoline

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Aromatic Heterocycles Piperidines Pyrimidines Quinolines Spiroes Tetrahydroquinolines

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Alcohols Amides Amines Aryls Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Ketones Nitriles Nitroes Phenols Sulfamides Trifluoromethyls

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