Nurr1 (also known as NR4A2) is a member of the nuclear receptor family 4A subfamily, acting as a transcription factor primarily expressed in dopaminergic neurons in the brain. Nurr1 contains a DNA-binding domain and a ligand-binding domain, although its activity does not depend on ligand binding. Nurr1 plays a crucial role in the development and maintenance of dopaminergic neurons, participating in dopamine signal transduction by regulating the expression of genes related to dopamine synthesis and metabolism. The gene expression of Nurr1 is regulated by various signaling pathways, and mutations or abnormal expression of Nurr1 are associated with neurodegenerative diseases such as Parkinson's disease.