Home Chemistry Organometallic Reagents Organoborons 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
Suzuki-Miyaura Cross-Coupling Reaction: This reaction involves coupling the boron-containing compound with an aryl or vinyl halide or triflate in the presence of a palladium catalyst, typically a Pd(PPh3)4 complex. The reaction forms a new carbon-carbon bond between the boron atom and the halide or triflate, resulting in the incorporation of the indole moiety into more complex molecules.
Boronic Acid Pinacol Ester Formation: The compound can be converted into its boronic acid pinacol ester derivative, which is a valuable intermediate in various synthetic transformations. This can be achieved by treating it with pinacolborane (HBPin) in the presence of a Lewis acid or base.
Hydrolysis: The boron-oxygen bond in the boron-containing compound can be hydrolyzed under acidic or basic conditions, leading to the cleavage of the boron atom from the indole ring.
Functionalization Reactions: Various functional groups can be introduced onto the indole ring using standard synthetic methods. For example, halogenation, alkylation, acylation, and other substitution reactions can be performed on the indole ring.
Reduction Reactions: The compound can undergo reduction reactions, such as the reduction of the boron atom to its corresponding boronic acid or alcohol derivative using reducing agents like sodium borohydride (NaBH4).
Formation of Complexes: The boron atom in the compound can form complexes with various Lewis bases or Lewis acids, leading to the generation of structurally interesting and potentially reactive species.
Framework+−
By Key Group+−
By Parent Nucleus+−
Formula Weight+−
click to sign in and save
6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
click to sign in and save
Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate
click to sign in and save
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
click to sign in and save
3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
click to sign in and save
Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-3-carboxylate
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :