The Glycine transporter family is responsible for regulating the concentration of glycine in the nervous system, mainly including two subtypes, GlyT1 and GlyT2. They are composed of multiple transmembrane domains, with GlyT1 primarily located on glial cells and GlyT2 primarily located on neurons. These transporters participate in inhibitory neurotransmission and the modulation of neuronal excitability by transporting glycine from the synaptic cleft back into the cell. The expression of glycine transporters is tissue- and cell-specific, and mutations or dysregulation of their genes are associated with various neurological disorders, including schizophrenia, cognitive impairments, and hereditary sensory neuropathy.