Home Chemistry Heterocyclic Building Blocks Piperidines Piperidin-4-Ylmethanamine
Acylation: The primary amine group can undergo acylation reactions with acyl chlorides or anhydrides to form amides.
Alkylation: The primary amine group can undergo alkylation reactions with alkyl halides or alkyl sulfonates to form secondary or tertiary amines.
Reductive Amination: The compound can undergo reductive amination reactions with carbonyl compounds (aldehydes or ketones) in the presence of reducing agents such as sodium cyanoborohydride to form secondary amines.
Mannich Reaction: The compound can participate in Mannich reactions where it reacts with formaldehyde and a compound containing an acidic hydrogen (such as a ketone or aldehyde) to form β-amino ketones or alcohols.
Ring-Opening Reactions: The piperidine ring can undergo ring-opening reactions under certain conditions, leading to the formation of compounds with open-chain structures.
Redox Reactions: The amine group can participate in redox reactions, either as an oxidant or a reductant, depending on the reaction conditions.
Nucleophilic Substitution: The amine group can act as a nucleophile in substitution reactions, particularly in reactions involving electrophiles.
Imine Formation: The primary amine group can react with carbonyl compounds to form imines.
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(1-Methylpiperidin-4-yl)methanamine dihydrochloride
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2-[4-(Aminomethyl)piperidin-1-yl]acetonitrile 2HCl
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