Home Chemistry Heterocyclic Building Blocks Indolines 1-Benzylindoline-2,3-Dione
Nucleophilic Addition: The carbonyl group can undergo nucleophilic addition reactions with nucleophiles such as Grignard reagents, amines, and hydride sources to form alcohol, amine, or alkane derivatives, respectively.
Aldol Condensation: The carbonyl group can participate in aldol condensation reactions with other carbonyl compounds in the presence of a base, resulting in the formation of β-hydroxyketones or β-diketones.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Oxidation: The indoline moiety or the adjacent carbon atoms can undergo oxidation reactions to form various functional groups, such as ketones or carboxylic acids.
Ring Opening: The indoline ring can potentially undergo ring-opening reactions under certain conditions, yielding compounds with open-chain structures.
Substitution Reactions: The benzyl group can be subjected to substitution reactions, such as halogenation or nucleophilic aromatic substitution, resulting in substituted benzylindoline-2,3-dione derivatives.
Cyclization Reactions: Depending on the reaction conditions and reagents used, it's possible to perform intramolecular cyclization reactions to form fused ring systems or other cyclic compounds.
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