CYTH family members, known as Pleckstrin Homology domain-containing family C, include various isoforms such as CYTH1, CYTH2, etc. These proteins, which contain specific PH domains, are primarily located near the cell membrane and are involved in cellular signaling. CYTH proteins play a crucial role in regulating intracellular lipid signaling, cell migration, and differentiation. They exhibit specific expression across various cell types, and mutations may affect their signaling functions, associating with the development of certain cancers.