Home Chemistry Organic Building Blocks Bromides 2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—CF3).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Nucleophilic Aromatic Substitution (SNAr): Depending on the nature of the nucleophile, nucleophilic aromatic substitution reactions can occur. The trifluoromethyl group can influence the reactivity and regioselectivity of these reactions.
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1-Bromo-2-fluoro-4-nitro-5-(trifluoromethyl)benzene
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2-Bromo-1-fluoro-4-(trifluoromethyl)benzene
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1-Bromo-2-fluoro-3-nitro-5-(trifluoromethyl)benzene
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