Home Chemistry Heterocyclic Building Blocks Aliphatic Heterocycles 4-Benzyl-1,4-Oxazepane
Nucleophilic Substitution: The oxygen and nitrogen atoms in the oxazepane ring can act as nucleophiles and participate in nucleophilic substitution reactions. For example, you can react 4-benzyl-1,4-oxazepane with alkyl halides to form substituted oxazepanes.
Ring Opening: The seven-membered oxazepane ring can undergo ring-opening reactions under certain conditions. This can be achieved by treating the compound with strong nucleophiles or acids.
Reduction: The benzyl group in 4-benzyl-1,4-oxazepane can be reduced to form a substituted tetrahydrooxazepane. This reduction can be carried out using reducing agents such as lithium aluminum hydride (LiAlH4).
Acylation and Alkylation: You can react 4-benzyl-1,4-oxazepane with acylating agents (e.g., acyl chlorides) or alkylating agents (e.g., alkyl halides) to introduce acyl or alkyl groups onto the nitrogen or oxygen atoms of the oxazepane ring.
Oxidation: The benzyl group can be oxidized to form a carboxylic acid or other oxidized products using suitable oxidizing agents.
Cyclization: Depending on the reaction conditions and the presence of other functional groups, 4-benzyl-1,4-oxazepane can undergo cyclization reactions to form different heterocyclic compounds.
Grignard Reactions: You can react 4-benzyl-1,4-oxazepane with Grignard reagents to introduce various functional groups onto the benzyl carbon atom.
Amide Formation: The nitrogen atom in the oxazepane ring can react with acyl chlorides or anhydrides to form amides.
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4-Benzyl-2-(chloromethyl)homomorpholine
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