DDR1 and DDR2 receptors are members of the receptor tyrosine kinase family, specifically recognizing and binding to collagen. They participate in processes such as cell adhesion, proliferation, and migration through phosphorylation-mediated signal transduction. DDR1 is primarily expressed in epithelial cells, while DDR2 is more abundant in mesenchymal cells, such as fibroblasts. These receptors play significant roles in tissue remodeling and disease progression, including tumor formation and fibrosis. The specificity of gene expression and mutations can affect receptor function, being related to the development of various diseases.