ITPKA (Inositol-trisphosphate 3-kinase A) is a member of the inositol phosphate kinase family, responsible for catalyzing the conversion of inositol 1,4,5-trisphosphate (IP3) into inositol 1,3,4,5-tetrakisphosphate (IP4), involved in regulating intracellular calcium concentration and signaling pathways. Composed of a kinase activity domain and a regulatory domain, ITPKA is primarily located in neuronal cells, especially concentrated at synaptic sites. It plays roles in neural development, learning and memory, and cell migration. The gene expression of ITPKA is tissue-specific, with aberrant expression or mutations associated with an increased risk of neurological disorders, including certain psychiatric conditions and cancers.