Home Chemistry Organic Building Blocks Trifluoromethyls 1-Fluoro-3-(Trifluoromethyl)Benzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CF3).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Friedel-Crafts Acylation/Alkylation: The (trifluoromethyl)benzene can undergo Friedel-Crafts acylation or alkylation reactions, in which an acyl or alkyl group is added to the benzene ring. These reactions are catalyzed by Lewis acids and result in the formation of new carbon-carbon bonds.
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3-Fluoro-5-(trifluoromethyl)phenyl isocyanate
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1-Fluoro-3-methoxy-5-(trifluoromethyl)benzene
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Methyl 2-fluoro-4-(trifluoromethyl)benzoate
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5-Fluoro-3-(trifluoromethyl)benzene-1,2-diamine
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2-Fluoro-4-(trifluoromethyl)benzoic acid
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4-Fluoro-1-methyl-2-(trifluoromethyl)benzene
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