Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-3-Fluoropyridin-4-Amine
Substitution Reactions: The chlorine and fluorine atoms can undergo substitution reactions with various nucleophiles or electrophiles. For example, nucleophilic substitution reactions with primary or secondary amines can lead to the formation of substituted amino groups.
Reductive Amination: The amine group can undergo reductive amination reactions with carbonyl compounds (aldehydes or ketones) in the presence of reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride, to form secondary or tertiary amines.
Cross-Coupling Reactions: The amine can undergo cross-coupling reactions with aryl halides or pseudohalides, such as Suzuki-Miyaura coupling or Buchwald-Hartwig amination, to form biaryl or arylamine compounds.
Nucleophilic Aromatic Substitution (SNAr): The pyridine ring can undergo nucleophilic aromatic substitution reactions with suitable nucleophiles under appropriate conditions.
Acylation Reactions: The amine group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Redox Reactions: The compound can participate in various redox reactions, depending on the conditions and the reactants involved.
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Methyl 4-amino-6-chloro-5-fluoronicotinate
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Ethyl 4-amino-6-chloro-5-fluoronicotinate
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