Home Chemistry Organic Building Blocks Chlorides 1-Chloro-2-Fluoro-4-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—F,—NO2).
Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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1-Chloro-2-fluoro-5-methyl-4-nitrobenzene
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N-(5-Chloro-4-fluoro-2-nitrophenyl)acetamide
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(5-Chloro-4-fluoro-2-nitrophenyl)boronic acid
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