Home Chemistry Organic Building Blocks Ethers 1-Fluoro-2-(Trifluoromethoxy)Benzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—OCF3).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Cross-Coupling Reactions: Trifluoromethoxybenzene can be used as a substrate in various cross-coupling reactions, such as Suzuki-Miyaura coupling, Heck coupling, or Buchwald-Hartwig amination. These reactions can introduce various substituents onto the benzene ring.
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4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene
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3,5-Difluoro-4-(trifluoromethoxy)phenol
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2,4-Difluoro-5-(trifluoromethoxy)aniline
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2-Fluoro-3-(trifluoromethoxy)benzoic acid
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(3-Fluoro-4-(trifluoromethoxy)phenyl)boronic acid
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2-Fluoro-5-bromo-trifluoromethoxybenzene
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5-Bromo-1,3-difluoro-2-(trifluoromethoxy)benzene
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1-Bromo-2,5-difluoro-4-(trifluoromethoxy)benzene
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