Home Chemistry Organic building blocks Bromides 2-bromo-4-fluoro-1-nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—NO2,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Halogenation: Nitrobenzene can undergo halogenation reactions, where halogen atoms (such as chlorine or bromine) are substituted onto the benzene ring. This is usually achieved using halogenating agents in the presence of a catalyst.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
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2-Bromo-4-fluoro-1-nitro-3-(trifluoromethyl)benzene
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1-Bromo-5-fluoro-2-nitro-4-(trifluoromethyl)benzene
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Methyl 4-bromo-2-fluoro-5-nitrobenzoate
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1-Bromo-4-chloro-5-fluoro-2-nitrobenzene
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1-Bromo-5-fluoro-4-methoxy-2-nitrobenzene
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1,4-Dibromo-2,3-difluoro-5,6-dinitrobenzene
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1-Bromo-2,3,4,5-tetrafluoro-6-nitrobenzene
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