Home Chemistry Heterocyclic Building Blocks Pyridines 4-Nitropyridine
Nitration: Being a nitroaromatic compound, 4-nitropyridine can undergo further nitration under appropriate conditions, typically by reacting with a nitrating agent like concentrated nitric acid. This can result in the introduction of additional nitro groups onto the pyridine ring.
Reduction: The nitro group in 4-nitropyridine can be reduced to an amino group (-NH2) under various reduction conditions, such as using catalytic hydrogenation with a metal catalyst (e.g., palladium on carbon), or with reducing agents like iron and hydrochloric acid (Fe/HCl).
Substitution Reactions: The nitro group can undergo substitution reactions with various nucleophiles under suitable conditions. For example, it can be replaced by hydrogen under catalytic hydrogenation conditions, or by other nucleophiles like thiols or amines under appropriate reaction conditions.
Electrophilic Aromatic Substitution: Similar to other aromatic compounds, 4-nitropyridine can undergo electrophilic aromatic substitution reactions. For instance, it can react with strong electrophiles like Lewis acids or acylating agents to form substituted products.
Metal Complexation: The nitrogen atom in the pyridine ring can act as a ligand in coordination complexes with transition metals, forming metal complexes. This can lead to various coordination chemistry-based reactions and applications.
Oxidation: 4-nitropyridine can undergo oxidation reactions under certain conditions, leading to the formation of products with higher oxidation states. This can involve the oxidation of the nitrogen or carbon atoms in the molecule.
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