MRGPR (Mas-related G protein-coupled receptor) is a group of members of the G protein-coupled receptor family, including several subtypes such as MRGPRX1, MRGPRX2, etc. They possess seven transmembrane domains and are mainly expressed in sensory neurons and immune cells. MRGPR receptors participate in regulating pain, itch sensation, and inflammatory responses by activating signaling pathways such as ERK, JNK, etc. The specific expression and regulation of MRGPR play an important role in allergic reactions, pain, and skin diseases. Mutations or aberrant expression of MRGPR are associated with the development of various sensory nerve and immune-related diseases.