Home Chemistry Heterocyclic Building Blocks Piperidines Azepane
N-Alkylation: Azepane can be alkylated at the nitrogen atom with alkyl halides or alkylating agents to form N-substituted azepanes.
Reductive Amination: Azepane can participate in reductive amination reactions, where it reacts with a carbonyl compound (e.g., aldehydes or ketones) and a reducing agent (e.g., sodium borohydride) to form secondary or tertiary amines.
Ring-Opening Reactions: Azepane can undergo ring-opening reactions under certain conditions. For example, it can be opened using strong acids or with certain nucleophiles.
Acylation: Azepane can react with acylating agents (e.g., acyl halides or anhydrides) to form amides.
Hofmann Elimination: Treatment of N-substituted azepanes with halogens and a strong base can lead to Hofmann elimination reactions, resulting in the formation of primary amines.
Ring Expansion: Azepane can be converted into larger ring compounds through ring expansion reactions. For example, it can be transformed into octane derivatives.
Amidation: Azepane can undergo amidation reactions to form secondary and tertiary amides.
Mannich Reaction: Azepane can participate in the Mannich reaction, which involves the condensation of azepane with formaldehyde and a secondary amine or ammonia to form β-amino carbonyl compounds.
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1-tert-Butyl 4-ethyl azepane-1,4-dicarboxylate
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Azepane-4-carboxylic acid hydrochloride
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(S)-tert-Butyl 3-aminoazepane-1-carboxylate
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tert-Butyl 4-aminoazepane-1-carboxylate
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(R)-1-(tert-Butoxycarbonyl)azepane-2-carboxylic acid
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tert-Butyl (S)-azepan-3-ylcarbamate hydrochloride
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