GPR88 is an orphan G protein-coupled receptor, specifically expressed in the central nervous system, particularly in the striatum and other brain regions. It contains seven transmembrane domains and does not bind to known endogenous ligands. GPR88 is involved in regulating neuronal activity and behavioral responses, such as motor control, emotional regulation, and cognitive function. The activation and signaling mechanisms of GPR88 are not fully understood, but its role in neurodevelopment and function is gradually being revealed. The specific expression of the gene and its distribution in the nervous system suggest its association with various neuropsychiatric disorders, including schizophrenia, depression, and addiction. Mutations or expression changes may affect the stability of neural circuits and behavioral performance.