Home Chemistry Heterocyclic Building Blocks Quinolines 4-Phenoxyquinoline
Substitution Reactions: 4-Phenoxyquinoline contains a phenolic group (-OH) and a quinoline ring, both of which can undergo substitution reactions. For example, it can undergo electrophilic aromatic substitution reactions where the hydrogen or the phenoxy group can be replaced by other functional groups (e.g., halogenation, nitration, sulfonation) under appropriate reaction conditions.
Alkylation/Acylation: The phenolic oxygen can be alkylated or acylated to introduce alkyl or acyl groups to the molecule. This can be achieved using alkyl halides or acyl chlorides in the presence of a suitable base or catalyst.
Reduction: The quinoline ring can be reduced to form dihydroquinoline derivatives. Reduction can be accomplished using reducing agents such as lithium aluminum hydride (LiAlH4) or catalytic hydrogenation.
Oxidation: The phenolic group can be oxidized to form quinone derivatives. Common oxidizing agents like potassium permanganate (KMnO4) or chromium(VI) reagents can be used for this purpose.
Grignard Reactions: 4-Phenoxyquinoline can react with Grignard reagents (organomagnesium compounds) to form various organometallic derivatives.
Condensation Reactions: It can participate in condensation reactions, such as the synthesis of Schiff bases or Mannich bases, by reacting with appropriate reagents.
Metalation: The nitrogen atom in the quinoline ring can act as a coordination site for various metal ions, allowing for the formation of metal complexes.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Heterocyclic related+−
Formula Weight+−
click to sign in and save
4-(4-Amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide
click to sign in and save
4-[(7-Chloroquinolin-4-yl)oxy]-3-fluoroaniline
click to sign in and save
4-(3-Fluoro-4-nitrophenoxy)-6,7-dimethoxyquinoline hydrochloride
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :