The FKBP family (FK506 binding proteins) is a group of proteins that exhibit binding activity to the immunosuppressants FK506 and Rapamycin. These proteins mediate protein folding and stability through their peptidyl-prolyl cis-trans isomerase activity domain. Family members are widely distributed in various cellular locations including the cytoplasm, nucleus, and mitochondria, affecting biological processes such as cellular responses, signal transduction, and protein degradation. The expression of FKBP shows specificity in different tissues, and dysregulation of its function and gene mutations are associated with neurodegenerative diseases, cancer, autoimmune diseases, and others. FKBP family members serve as drug targets, holding significant importance in regulating immune responses and developing therapeutic drugs.