Home Chemistry Heterocyclic building blocks Pyrrolidines Tert-butyl 3-hydroxypyrrolidine-1-carboxylate
Ester Hydrolysis: Under acidic or basic conditions, the ester group can undergo hydrolysis to form the corresponding carboxylic acids and alcohols.
Substitution Reactions: The tert-butyl group can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution.
Ring-opening Reactions: The pyrrolidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Reduction: The carbonyl group of the carboxylate can be reduced to the corresponding alcohol under appropriate conditions.
Oxidation: The hydroxyl group can be oxidized to form a carbonyl group under suitable conditions.
Decarboxylation: Under certain conditions, such as heating or treatment with specific reagents, decarboxylation may occur, leading to the loss of the carboxyl group and formation of the corresponding alkylamine.
Esterification: The carboxylate group can react with alcohols to form esters through esterification reactions.
Protection Reactions: The tert-butyl group can serve as a protecting group for the hydroxyl functionality, allowing selective reactions at other functional groups.
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tert-Butyl 3-hydroxypyrrolidine-1-carboxylate
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tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
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(3R,4R)-rel-tert-Butyl 3-hydroxy-4-methylpyrrolidine-1-carboxylate
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(3R,4S)-rel-tert-Butyl 3-hydroxy-4-methylpyrrolidine-1-carboxylate
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trans-1-tert-Butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate
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(3S,4S)-tert-Butyl 3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
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rel-(3R,4S)-tert-Butyl 3,4-dihydroxypyrrolidine-1-carboxylate
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(3R,4R)-rel-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
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1-(tert-Butyl) 3-ethyl (3R,4S)-4-hydroxypyrrolidine-1,3-dicarboxylate
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(2S,3R)-1-tert-Butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate
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Ethyl 1-Boc-4-hydroxypyrrolidine-3-carboxylate
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(3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
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