Home Chemistry Organic Building Blocks Chlorides Phenyl Carbonochloridate
These compounds have the same murcko framework: benzene,and at least 1 kind of functional groups( —OC(O)Cl).
Acylation Reactions: Phenyl carbonochloridate can be used to introduce an acyl group (RC(O)-) onto various nucleophiles, such as 【amines|https://www.ambeed.com/amines.html】, 【alcohols|https://www.ambeed.com/alcohols.html】, and 【thiols|https://www.ambeed.com/thiols.html】, to form 【Amides|https://www.ambeed.com/amides.html】, 【esters|https://www.ambeed.com/esters.html】, and thioesters, respectively. The reaction typically involves the displacement of the chlorine atom by the nucleophile.
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3-(Trifluoromethyl)phenyl carbonochloridate
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