Home Chemistry Heterocyclic Building Blocks Oxazolidines 3-Phenyloxazolidin-2-One
Reduction: You can reduce the oxazolidin-2-one ring using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) to obtain a corresponding amine or alcohol.
Acylation: You can react 3-phenyloxazolidin-2-one with acylating agents, such as acyl chlorides or anhydrides, to introduce an acyl group into the molecule.
Ring Opening: The oxazolidin-2-one ring can be opened under certain conditions to form a linear compound. For instance, the ring can be opened through nucleophilic attack.
Amine Derivatives: You can convert 3-phenyloxazolidin-2-one into various amine derivatives by reacting it with appropriate aminating agents.
Nucleophilic Substitution: If you have a suitable leaving group on the molecule, you can perform nucleophilic substitution reactions to replace the leaving group with another nucleophile.
Cyclization: Depending on the reaction conditions and reagents used, 3-phenyloxazolidin-2-one can be cyclized to form other heterocyclic compounds.
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(R)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
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(R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
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(S)-N-((3-(3,5-Difluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
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