Home Chemistry Organic Building Blocks Bromides 2-Bromo-1-Chloro-4-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—Cl,—NO2).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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1-Bromo-2-chloro-4-methyl-5-nitrobenzene
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1-Bromo-2-chloro-3-methoxy-5-nitrobenzene
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1-Bromo-2-chloro-4-iodo-5-nitrobenzene
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