Home Chemistry Heterocyclic Building Blocks Piperidines Piperidin-3-One
Reduction: Piperidin-3-one can be reduced to piperidin-3-ol (3-piperidinol) using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Amination: Piperidin-3-one can undergo amination reactions to introduce amino groups at various positions on the piperidine ring. This can be achieved using appropriate amine reagents and catalysts.
Condensation: Piperidin-3-one can participate in condensation reactions with various carbonyl compounds to form a wide range of heterocyclic compounds.
Alkylation: Piperidin-3-one can be alkylated by reacting it with alkyl halides or other alkylating agents, leading to the introduction of alkyl groups on the piperidine ring.
Acylation: Piperidin-3-one can be acylated by reacting it with acyl chlorides or anhydrides, resulting in the formation of amides or esters.
Ring-closure reactions: Piperidin-3-one can undergo intramolecular cyclization reactions to form various cyclic compounds, including lactams and fused ring systems.
Reactions with nucleophiles: The ketone group in piperidin-3-one can react with nucleophiles such as Grignard reagents, hydrazines, and organolithium compounds to form new products.
Oxidation: Piperidin-3-one can be oxidized to form piperidin-3-one derivatives with different oxidation states.
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Ethyl 3-oxopiperidine-4-carboxylate hydrochloride
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1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate
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tert-Butyl 4-methyl-3-oxopiperidine-1-carboxylate
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1-tert-Butyl 3-methyl 5-oxopiperidine-1,3-dicarboxylate
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tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate
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tert-Butyl 2-methyl-3-oxopiperidine-1-carboxylate
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Methyl N-Boc-3-Oxopiperidine-4-carboxylate
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(S)-1-tert-Butyl 2-ethyl 5-oxopiperidine-1,2-dicarboxylate
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(S)-tert-Butyl 3-methyl-5-oxopiperidine-1-carboxylate
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