The ATF/CREB (Activating Transcription Factor/cAMP Response Element-Binding Protein) family is a group of bZIP (basic leucine zipper) transcription factors, including multiple members such as ATF1, ATF2, CREB1, and CREB2. They consist of a DNA-binding domain, a leucine zipper domain, and a transcription activation domain, primarily located in the cell nucleus. The ATF/CREB family is involved in regulating various biological responses and signaling pathways, such as cell stress response, cell cycle control, neuronal signal transduction, and metabolic regulation, by binding to specific cAMP response elements (CRE) to affect the expression of downstream genes. In different tissues and cells, the expression of ATF/CREB family members is specific, and mutations or dysregulation in their expression are associated with various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.