Home Chemistry Heterocyclic Building Blocks Thiadiazoles 2-Phenyl-1,3,4-Thiadiazole
Substitution Reactions: The phenyl ring in 2-phenyl-1,3,4-thiadiazole can undergo electrophilic aromatic substitution reactions. For example, it can react with strong electrophiles like nitronium ion (NO2+) or acyl halides to introduce substituents on the phenyl ring.
Reduction Reactions: The thiadiazole ring can be reduced to form 2-phenyl-1,3,4-thiadiazoline under appropriate conditions. Common reducing agents like hydrogen gas H2 in the presence of a catalyst or hydrazine (N2H4) can be used for this purpose.
Oxidation Reactions: The thiadiazole ring can be oxidized to form 2-phenyl-1,3,4-thiadiazole-5-carboxylic acid or its derivatives by using strong oxidizing agents like potassium permanganate (KMnO4) or hydrogen peroxide (H2O2).
Acylation and Alkylation Reactions: 2-phenyl-1,3,4-thiadiazole can undergo acylation or alkylation reactions at the nitrogen atoms of the thiadiazole ring. For example, it can react with acyl chlorides or alkyl halides to introduce acyl or alkyl groups, respectively.
Condensation Reactions: It can participate in condensation reactions with suitable reagents to form derivatives such as Schiff bases or Mannich bases.
Cyclization Reactions: Depending on the reaction conditions and reagents, 2-phenyl-1,3,4-thiadiazole can undergo cyclization reactions to form various cyclic compounds.
Functional Group Transformations: The compound can undergo transformations of functional groups present in the molecule, such as conversion of the thiol group to disulfides or sulfoxides.
Metal Complexation: 2-phenyl-1,3,4-thiadiazole can also form complexes with various transition metals, which can have applications in coordination chemistry and catalysis.
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5-(2,4-Dichlorophenyl)-1,3,4-thiadiazol-2-amine
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5-(4-(tert-Butyl)phenyl)-1,3,4-thiadiazol-2-amine
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5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine
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3-(5-Amino-1,3,4-thiadiazol-2-yl)benzonitrile
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5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-amine
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5-(3-Methoxyphenyl)-1,3,4-thiadiazol-2-amine
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5-(2,3-Dichlorophenyl)-1,3,4-thiadiazol-2-amine
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5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine
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5-(3-Nitrophenyl)-1,3,4-thiadiazol-2-amine
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5-(4-Isopropylphenyl)-1,3,4-thiadiazol-2-amine
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