The HSF (Heat Shock Factor) family includes multiple members such as HSF1, HSF2, and HSF4, all featuring a characteristic DNA-binding domain. HSF is primarily located in the nucleus, responding to heat shock and other stress conditions by activating the expression of heat shock proteins to help cells combat protein damage. Additionally, HSF is involved in regulating cell growth and development. The expression of HSF is tissue-specific, and mutations in its genes can lead to various diseases, including neurodegenerative diseases and cancer.