The mitochondrial pyruvate carrier (MPC) is a transmembrane protein complex, primarily composed of two subunits, MPC1 and MPC2, located in the inner mitochondrial membrane. It is responsible for transporting pyruvate from the cytoplasm into the mitochondria, serving as a crucial link in metabolic pathways such as glycolysis and the tricarboxylic acid cycle. MPC expression is tissue- and cell-type-specific, and mutations in its genes are closely associated with various metabolic diseases and tumorigenesis. Studies have shown that the activity and expression levels of MPC impact cellular energy metabolism and growth signal transduction.