Home Chemistry Heterocyclic Building Blocks Pyrroles 1-(Phenylsulfonyl)-1H-Pyrrole
Nucleophilic Substitution: The phenylsulfonyl group can be replaced by a nucleophile (e.g., amines, thiols, or other nucleophiles) through a nucleophilic substitution reaction.
Reductive Cleavage: The sulfonyl group can be reduced to form a primary amine. Common reducing agents include sodium borohydride (NaBH4) or hydrogen gas H2 with a metal catalyst.
Oxidation: The pyrrole ring may undergo oxidation reactions to form various products, depending on the oxidizing agent used.
Acylation: The pyrrole nitrogen can be acylated using acyl chlorides or anhydrides to introduce different substituents.
Metalation: The pyrrole ring can undergo metalation reactions, such as lithiation or boronation, to introduce various functional groups.
Condensation Reactions: 1-(phenylsulfonyl)-1H-pyrrole can participate in various condensation reactions, such as the Vilsmeier-Haack reaction, to introduce different substituents on the pyrrole ring.
Cross-Coupling Reactions: It can be used in various palladium-catalyzed cross-coupling reactions to form C-C or C-N bonds with different organic or organometallic reagents.
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1-((5-Bromo-2-methoxyphenyl)sulfonyl)pyrrolidine
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(3-(Pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(5-(Methoxycarbonyl)-1-tosyl-1H-pyrrol-3-yl)boronic acid
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(2-Methyl-5-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(4-Methoxy-3-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(S)-1-(Phenylsulfonyl)pyrrolidin-3-amine hydrochloride
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(3-Methyl-4-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(4-(Pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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1-(3-Bromo-4-methylphenylsulfonyl)pyrrolidine
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(2-(Pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(2-Methyl-4-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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