The Bombein receptors refer to receptors that bind with Gastrin-Releasing Peptide (Bombesin) and its analogs, primarily including Gastrin-Releasing Peptide Receptor (GRPR), Neuromedin B Receptor (NMBR), and Neuropeptide Y Receptor, among others. These receptors belong to the G protein-coupled receptor (GPCR) family and have the typical seven-transmembrane domain structure. They are located in various tissues, including the central nervous system and the gastrointestinal tract, participating in the regulation of appetite, energy metabolism, cell proliferation, and differentiation, among other physiological and pathological processes. The signaling pathways involve cAMP, IP3/DAG, influencing calcium ion flux and the MAPK kinase pathway. Gene expression shows tissue specificity, and mutations or alterations in expression are associated with various diseases, such as cancer and metabolic disorders.