Chemistry Heterocyclic Building Blocks Pyrazoles 5-Cyclopropyl-1H-Pyrazole

5-Cyclopropyl-1H-Pyrazole

Substitution Reactions: Depending on the substituents attached to the cyclopropyl and pyrazole rings, 5-cyclopropyl-1H-pyrazole can undergo nucleophilic substitution reactions. For example, if there is a halogen substituent (e.g., chlorine or bromine), it can undergo nucleophilic substitution with a nucleophile. Acylation and Alkylation: 5-cyclopropyl-1H-pyrazole can react with acylating agents (e.g., acyl chlorides) to form amides or with alkylating agents to form alkyl derivatives. Oxidation Reactions: Depending on the reaction conditions and functional groups present, oxidation reactions can occur. For example, it might be oxidized to form pyrazole oxides or other oxidation products. Reduction Reactions: 5-cyclopropyl-1H-pyrazole can undergo reduction reactions with reducing agents to form reduced derivatives. Cycloaddition Reactions: It can participate in cycloaddition reactions, such as Diels-Alder reactions, if the reaction conditions and substrates are appropriate. Ring-Opening Reactions: Under certain conditions, the cyclopropyl ring can undergo ring-opening reactions, leading to the formation of open-chain compounds. Condensation Reactions: It can participate in condensation reactions with suitable reagents to form new heterocyclic compounds. Metal-Catalyzed Reactions: Transition metal catalysts can facilitate various reactions with 5-cyclopropyl-1H-pyrazole, such as cross-coupling reactions, C-H activation, and more.

Further Reading:

Framework+−

(1-Methyl-1H-Pyrazol-3-Yl)Methanol (1-Phenyl-1H-Pyrazol-4-Yl)Boronic Acid 1,3-Dimethyl-1H-Pyrazole 1,3-Diphenyl-1H-Pyrazole 1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole 1,5-Diphenyl-1H-Pyrazole 1-(2-Chlorophenyl)-1H-Pyrazole 1-(3-Chlorophenyl)-1H-Pyrazole 1-(4-Methoxybenzyl)-1H-Pyrazole 1-(Azetidin-3-Yl)-1H-Pyrazole 1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole 1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazole 1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine 1-Benzyl-4-Bromo-1H-Pyrazole 1-Benzyl-4-Iodo-1H-Pyrazole 1-Cyclopentyl-1H-Pyrazole 1-Cyclopropyl-1H-Pyrazole 1-Methyl-1H-Pyrazol-3-Amine 1-Methyl-3-Phenyl-1H-Pyrazole 1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole 1-Methyl-5-Phenyl-1H-Pyrazole 1-Phenyl-1H-Pyrazol-3-Amine 1-Phenyl-1H-Pyrazol-3-Ol 1-Phenyl-1H-Pyrazol-5-Amine 1-Phenyl-1H-Pyrazole-3-Carboxylic Acid 1-Phenyl-1H-Pyrazole-4-Carbaldehyde 1-Phenyl-1H-Pyrazole-4-Carbonitrile 1-Phenyl-1H-Pyrazole-4-Carboxylic Acid 1-Phenyl-1H-Pyrazole-5-Carboxylic Acid 1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole 1-Trityl-1H-Pyrazole 1H-Pyrazol-4-Amine 1H-Pyrazol-4-Ol 1H-Pyrazol-5-Amine 1H-Pyrazole-4-Carbaldehyde 1H-Pyrazole-4-Carbonitrile 1H-Pyrazole-4-Carboxylic Acid 1H-Pyrazole-4-Sulfonyl Chloride 1H-Pyrazole-5-Carboxamide 1H-Pyrazole-5-Carboxylic Acid 1H-Pyrazolo[3,4-B]Pyrazine 1H-Pyrazolo[3,4-B]Pyridin-5-Amine 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine 1H-Pyrazolo[4,3-D]Pyrimidine 2,3-Dihydropyrazolo[5,1-B]Oxazole 2,4-Dihydro-3H-Pyrazol-3-One 2,6-Di(1H-Pyrazol-1-Yl)Pyridine 2-(1H-Pyrazol-1-Yl)Pyridine 2-(1H-Pyrazol-1-Yl)Pyrimidine 2-(1H-Pyrazol-3-Yl)Pyridine 2-Phenyl-2,4-Dihydro-3H-Pyrazol-3-One 3-(Tert-Butyl)-1-Phenyl-1H-Pyrazole 3-Bromo-1-Methyl-1H-Pyrazole 3-Bromopyrazolo[1,5-A]Pyridine 3-Bromopyrazolo[1,5-A]Pyrimidine 3-Chloro-1-Methyl-1H-Pyrazole 3-Cyclopropyl-1H-Pyrazole 3-Iodo-1-Methyl-1H-Pyrazole 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine 3-Methyl-1-Phenyl-1H-Pyrazole 3-Phenyl-1H-Pyrazol-5-Amine 4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine 4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine 4-(1H-Pyrazol-1-Yl)Benzoic Acid 4-(1H-Pyrazol-1-Yl)Piperidine 4-Bromo-1-Methyl-1H-Pyrazole 4-Bromo-1-Phenyl-1H-Pyrazole 4-Bromo-1H-Pyrazolo[3,4-B]Pyridine 4-Bromopyrazolo[1,5-A]Pyridine 4-Chloro-1H-Pyrazole 4-Chloro-1H-Pyrazolo[3,4-B]Pyridine 4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 4-Iodo-1H-Pyrazole 4-Methyl-1-Phenyl-1H-Pyrazole 4-Methyl-1H-Pyrazole 4-Nitro-1H-Pyrazole 4-Phenyl-1H-Pyrazole 5,6-Dihydro-4H-Pyrrolo[1,2-B]Pyrazole 5-(Difluoromethyl)-1H-Pyrazole 5-Bromo-1H-Pyrazole 5-Bromo-1H-Pyrazolo[3,4-B]Pyridine 5-Bromo-1H-Pyrazolo[3,4-C]Pyridine 5-Chloro-1H-Pyrazole 5-Chloro-1H-Pyrazolo[3,4-B]Pyridine 5-Chloropyrazolo[1,5-A]Pyrimidine 5-Cyclopropyl-1H-Pyrazole 5-Iodo-1H-Pyrazole 5-Nitro-1H-Pyrazole 5-Nitro-1H-Pyrazolo[3,4-B]Pyridine 5-Phenyl-1H-Pyrazole-3-Carboxylic Acid 6,7-Dihydro-5H-Pyrazolo[5,1-B][1,3]Oxazine 6-Bromopyrazolo[1,5-A]Pyridine 6-Bromopyrazolo[1,5-A]Pyrimidine 6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 7-Chloropyrazolo[1,5-A]Pyrimidine Ethyl 1-Phenyl-1H-Pyrazole-3-Carboxylate Ethyl 1-Phenyl-1H-Pyrazole-4-Carboxylate Ethyl 1H-Pyrazole-4-Carboxylate Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate Methyl 1H-Pyrazole-4-Carboxylate Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate Pyrazolo[1,5-A]Pyrazine Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Carboxylate

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Aliphatic Heterocycles Aromatic Heterocycles Azetidines Furans Guanidines Imidazoles Indazoles Indoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxetanes Piperazines Piperidines Pyrazines Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Quinolines Tetrahydrofurans Tetrahydropyrans Thiophenes

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Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazones Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Sulfonyl Chlorides Trifluoromethyls Ureas

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