Home Chemistry Heterocyclic Building Blocks Indoles (1H-Indol-2-Yl)Boronic Acid
Suzuki-Miyaura Cross-Coupling Reaction: Boronic acids, including (1H-indol-2-yl)boronic acid, can undergo cross-coupling reactions with aryl halides or pseudohalides in the presence of a palladium catalyst. This reaction is widely used for the synthesis of biaryl compounds.
Chan-Lam Coupling: This reaction involves the coupling of boronic acids with amines in the presence of a copper catalyst. It is a useful method for the C-N bond formation.
Buchwald-Hartwig Amination: Boronic acids can react with amines in the presence of a palladium catalyst to form C-N bonds. This is another method for the synthesis of amines.
Borylation Reactions: Boronic acids can be used in borylation reactions to introduce boron atoms into organic molecules. This can be followed by further functionalization.
Hydrogenation: The indole ring in could potentially undergo hydrogenation reactions, depending on the reaction conditions and the catalyst used.
Oxidation Reactions: Boronic acids can be oxidized to corresponding boronate esters or boronic acid derivatives. This could be achieved using oxidizing agents.
Allylation or Acylation Reactions: Boronic acids can react with allyl or acyl halides to form the corresponding allyl or acyl boronates.
Reductive Amination: The boronic acid group can react with carbonyl compounds in the presence of a reducing agent to form secondary or tertiary amines.
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