Home Chemistry Heterocyclic Building Blocks Pyridines Pyridin-4-Ol
Acid-Base Reactions: The hydroxyl group can act as a Brønsted-Lowry base, accepting a proton to form the corresponding pyridin-4-ol cation or as an acid, donating a proton to form the pyridin-4-olate anion .
Substitution Reactions: The hydroxyl group can be substituted with various electrophiles, such as acyl chlorides or acid anhydrides, leading to the formation of esters or amides, respectively.
Oxidation Reactions: Pyridin-4-ol can undergo oxidation to form pyridine-4-carboxylic acid, where the hydroxyl group is oxidized to a carboxylic acid group. This can be achieved through various oxidizing agents such as chromic acid or potassium permanganate.
Esterification Reactions: The hydroxyl group can react with carboxylic acids in the presence of acid catalysts to form esters.
Reduction Reactions: Pyridin-4-ol can undergo reduction to form piperidine, a saturated heterocycle, typically through catalytic hydrogenation or other reducing agents.
Nucleophilic Substitution Reactions: The nitrogen atom in the pyridine ring can act as a nucleophile, participating in substitution reactions with various electrophiles.
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