Home Chemistry Heterocyclic building blocks Pyridines 2-fluoropyridine
Nucleophilic substitution reactions: The fluorine atom in 2-fluoropyridine can be substituted by various nucleophiles, such as alkoxides, amines, and thiols, leading to the formation of substituted pyridines.
Electrophilic aromatic substitution reactions: The electron-rich aromatic ring of 2-fluoropyridine can undergo electrophilic aromatic substitution reactions with electrophiles such as acyl halides, nitro groups, and sulfonic acids.
Metal-catalyzed cross-coupling reactions: 2-Fluoropyridine can participate in metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira reactions, to form biaryl or heteroaryl compounds.
Reduction reactions: The fluorine atom in 2-fluoropyridine can be reduced to other functional groups, such as hydrogen or methyl groups, using reducing agents like metal hydrides or hydrogen gas over a catalyst.
Halogenation reactions: The pyridine ring in 2-fluoropyridine can undergo halogenation reactions, such as bromination or iodination, at positions adjacent to the fluorine atom.
Oxidation reactions: 2-Fluoropyridine can undergo oxidation reactions to form various functional groups, such as ketones or carboxylic acids, under appropriate conditions.
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