GCase (β-glucocerebrosidase) is a member of the lysosomal enzyme family, responsible for breaking down lipid molecules attached to glucose, such as glucocerebrosides. Composed of two subunits, it is primarily located in the lysosomes, essential for maintaining normal cellular metabolism. The gene expression of GCase is tissue-specific, mainly found in the heart, liver, and nervous system. Mutations in the GCase gene can lead to Gaucher's disease, a genetic lipid storage disorder characterized by the accumulation of lipids in certain body cells. Furthermore, reduced activity of GCase is associated with an increased risk of neurodegenerative diseases like Parkinson's disease.