Chemistry Organic Building Blocks Fluorinated Building Blocks 2-Fluoro-4-Methylbenzoic Acid

2-Fluoro-4-Methylbenzoic Acid

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —F,—COOH,—CH3).

Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Decarboxylation: Under certain conditions, benzoic acid can undergo decarboxylation, where it loses a carbon dioxide molecule from its carboxylic acid group. This reaction usually requires high temperatures and is often observed in the presence of strong acids or bases.
Halogenation: Toluene can undergo halogenation reactions with halogens (such as chlorine or bromine) in the presence of a catalyst or under UV light. The hydrogen atoms on the benzene ring can be replaced by halogen atoms, resulting in the formation of mono-, di-, or polyhalogenated derivatives of toluene.

Further Reading:

Framework+−

(2,3-Difluorophenyl)Boronic Acid (2,6-Difluorophenyl)Boronic Acid (2-Chloro-6-Fluorophenyl)Boronic Acid (2-Fluorobenzyl)Hydrazine (2-Fluorophenyl)(Phenyl)Methanone (2-Fluorophenyl)Boronic Acid (2-Fluorophenyl)Hydrazine (2-Fluorophenyl)Methanamine (2-Fluorophenyl)Methanol (3-Fluorophenyl)(Phenyl)Methanone (3-Fluorophenyl)Boronic Acid (3-Fluorophenyl)Methanol (4-Fluorophenyl)(Phenyl)Methanone (4-Fluorophenyl)Boronic Acid (4-Fluorophenyl)Methanamine (4-Fluorophenyl)Methanol 1,1-Difluorocyclobutane 1,1-Difluorocyclohexane 1,2,3,4,5-Pentafluorobenzene 1,2,3,4-Tetrafluorobenzene 1,2,3-Trifluorobenzene 1,2,4-Trifluorobenzene 1,2-Dibromo-3-Fluorobenzene 1,2-Dibromo-4-Fluorobenzene 1,2-Dichloro-3-Fluorobenzene 1,2-Dichloro-4-Fluorobenzene 1,2-Difluoro-3-Iodobenzene 1,2-Difluoro-3-Methoxybenzene 1,2-Difluoro-3-Methylbenzene 1,2-Difluoro-3-Nitrobenzene 1,2-Difluoro-4-Methoxybenzene 1,2-Difluoro-4-Nitrobenzene 1,2-Difluorobenzene 1,3-Dibromo-2,4-Difluorobenzene 1,3-Dibromo-2-Fluorobenzene 1,3-Dichloro-2-Fluorobenzene 1,3-Difluoro-2-Iodobenzene 1,3-Difluoro-2-Methylbenzene 1,3-Difluoro-2-Nitrobenzene 1,4-Dichloro-2-Fluorobenzene 1,4-Difluoro-2-Iodobenzene 1,4-Difluoro-2-Nitrobenzene 1,4-Difluorobenzene 1-(2-Fluorophenyl)Ethan-1-Amine 1-(2-Fluorophenyl)Ethan-1-One 1-(2-Fluorophenyl)Piperazine 1-(2-Fluorophenyl)Propan-1-Amine 1-(3-Fluorophenyl)Ethan-1-One 1-(4-Fluorophenyl)Ethan-1-One 1-(Benzyloxy)-2-Fluorobenzene 1-(Benzyloxy)-3-Fluorobenzene 1-(Bromomethyl)-2-Fluorobenzene 1-(Bromomethyl)-3-Fluorobenzene 1-(Chloromethyl)-2-Fluorobenzene 1-(Chloromethyl)-3-Fluorobenzene 1-Benzyl-4-Fluorobenzene 1-Bromo-2,3-Difluorobenzene 1-Bromo-2,4-Difluorobenzene 1-Bromo-2-Chloro-3-Fluorobenzene 1-Bromo-2-Fluoro-3-Methylbenzene 1-Bromo-3-Fluoro-2-Methoxybenzene 1-Bromo-3-Fluoro-2-Methylbenzene 1-Bromo-3-Fluoro-2-Nitrobenzene 1-Bromo-4-Fluoro-2-Methoxybenzene 1-Bromo-4-Fluoro-2-Methylbenzene 1-Chloro-2,3-Difluorobenzene 1-Chloro-2,4-Difluorobenzene 1-Chloro-3-Fluoro-2-Methoxybenzene 1-Chloro-3-Fluoro-2-Methylbenzene 1-Cyclohexyl-2-Fluorobenzene 1-Ethoxy-2,3-Difluorobenzene 1-Ethoxy-2-Fluorobenzene 1-Ethynyl-2-Fluorobenzene 1-Fluoro-2,3-Dimethylbenzene 1-Fluoro-2-(Methylsulfonyl)Benzene 1-Fluoro-2-Iodo-4-Methylbenzene 1-Fluoro-2-Iodobenzene 1-Fluoro-2-Isopropoxybenzene 1-Fluoro-2-Methylbenzene 1-Fluoro-2-Phenoxybenzene 1-Fluoro-3,5-Dimethylbenzene 1-Fluoro-3-(Methylsulfonyl)Benzene 1-Fluoro-3-Iodo-2-Methylbenzene 1-Fluoro-3-Iodobenzene 1-Fluoro-3-Methoxybenzene 1-Fluoro-3-Methylbenzene 1-Fluoro-3-Nitrobenzene 1-Fluoro-3-Phenoxybenzene 1-Fluoro-4-Iodobenzene 1-Fluoro-4-Methoxybenzene 1-Fluoro-4-Methylbenzene 1-Fluoro-4-Phenoxybenzene 1-Fluorobicyclo[1.1.1]Pentane 1-Fluoronaphthalene 2'-Fluoro-1,1':4',1''-Terphenyl 2,2',3,3',5,5',6,6'-Octafluoro-1,1'-Biphenyl 2,3-Difluoroaniline 2,3-Difluorobenzaldehyde 2,3-Difluorobenzoic Acid 2,3-Difluorobenzonitrile 2,3-Difluorophenol 2,3-Difluoropyridine 2,4-Dibromo-1-Fluorobenzene 2,4-Dichloro-1-Fluorobenzene 2,4-Difluoro-1-Iodobenzene 2,4-Difluoro-1-Methoxybenzene 2,4-Difluoro-1-Nitrobenzene 2,4-Difluoroaniline 2,4-Difluorobenzaldehyde 2,4-Difluorobenzoic Acid 2,4-Difluorobenzonitrile 2,4-Difluorophenol 2,5-Difluoroaniline 2,5-Difluorobenzoic Acid 2,5-Difluoropyridine 2,6-Difluoroaniline 2,6-Difluorobenzaldehyde 2,6-Difluorobenzoic Acid 2,6-Difluorobenzonitrile 2,6-Difluorophenol 2,6-Difluoropyridine 2-(2-Fluorophenyl)Acetic Acid 2-(2-Fluorophenyl)Acetonitrile 2-(2-Fluorophenyl)Pyrrolidine 2-(3-Fluorophenyl)Acetic Acid 2-(3-Fluorophenyl)Pyrrolidine 2-(4-Fluorophenyl)-1H-Indole 2-(4-Fluorophenyl)Acetic Acid 2-(Bromomethyl)-1,3-Difluorobenzene 2-Amino-2-(2-Fluorophenyl)Acetic Acid 2-Amino-3-(2-Fluorophenyl)Propanoic Acid 2-Amino-3-Fluorobenzoic Acid 2-Bromo-1,3,4-Trifluorobenzene 2-Bromo-1,3-Difluorobenzene 2-Bromo-1,4-Difluorobenzene 2-Bromo-1-Chloro-3-Fluorobenzene 2-Bromo-1-Chloro-4-Fluorobenzene 2-Bromo-1-Fluoro-4-Methylbenzene 2-Bromo-4-Chloro-1-Fluorobenzene 2-Bromo-4-Fluoro-1-Methoxybenzene 2-Bromo-4-Fluoro-1-Methylbenzene 2-Bromo-4-Fluoroaniline 2-Bromo-4-Fluorobenzaldehyde 2-Bromo-4-Fluorobenzonitrile 2-Bromo-4-Fluorophenol 2-Bromo-5-Fluoroaniline 2-Bromo-5-Fluorobenzaldehyde 2-Bromo-5-Fluorobenzoic Acid 2-Bromo-6-Fluoroaniline 2-Bromo-6-Fluorophenol 2-Chloro-1,3-Difluorobenzene 2-Chloro-1,4-Difluorobenzene 2-Chloro-3-Fluoropyridine 2-Chloro-4-Fluoro-1-Methoxybenzene 2-Chloro-4-Fluoroaniline 2-Chloro-4-Fluorobenzaldehyde 2-Chloro-4-Fluorobenzoic Acid 2-Chloro-4-Fluorobenzonitrile 2-Chloro-4-Fluorophenol 2-Chloro-5-Fluoropyrimidine 2-Chloro-6-Fluoroaniline 2-Chloro-6-Fluorobenzoic Acid 2-Chloro-6-Fluorobenzonitrile 2-Chloro-6-Fluorophenol 2-Fluoro-1,3-Dimethoxybenzene 2-Fluoro-1,3-Dimethylbenzene 2-Fluoro-1-Iodo-4-Methylbenzene 2-Fluoro-3-Methylbenzaldehyde 2-Fluoro-3-Methylpyridine 2-Fluoro-4-Methoxyaniline 2-Fluoro-4-Methyl-1-Nitrobenzene 2-Fluoro-4-Methylbenzoic Acid 2-Fluoro-4-Methylpyridine 2-Fluoro-5-Methylpyridine 2-Fluoro-6-Methylpyridine 2-Fluoro-N-Methylbenzamide 2-Fluoro-N-Phenylaniline 2-Fluoro-N-Phenylbenzenesulfonamide 2-Fluoroaniline 2-Fluorobenzaldehyde 2-Fluorobenzamide 2-Fluorobenzenesulfonamide 2-Fluorobenzenesulfonyl Chloride 2-Fluorobenzoic Acid 2-Fluoropyridine 2-Fluoropyrimidine 3,3-Difluoropiperidine 3,3-Difluoropyrrolidine 3,4-Difluoroaniline 3,4-Difluorophenol 3,5-Difluoropyridine 3-((Tert-Butoxycarbonyl)Amino)-4-(2-Fluorophenyl)Butanoic Acid 3-Chloro-2-Fluoroaniline 3-Fluoro-1,1'-Biphenyl 3-Fluoro-2-Iodoaniline 3-Fluoro-2-Methylaniline 3-Fluoro-2-Methylpyridine 3-Fluoro-4-Nitroaniline 3-Fluoroaniline 3-Fluorobenzaldehyde 3-Fluorobenzamide 3-Fluorobenzenesulfonyl Chloride 3-Fluorobenzoic Acid 3-Fluorophenol 3-Fluoropiperidine 3-Fluoropyridin-2-Amine 3-Fluoropyridin-4-Amine 3-Fluorothiophene 4,4-Difluoropiperidine 4-(2-Fluorophenyl)Morpholine 4-(4-Fluorophenyl)Thiazole 4-Chloro-5-Fluoro-2-Methylpyrimidine 4-Fluoro-1-Methyl-2-Nitrobenzene 4-Fluoro-1H-Indazole 4-Fluoro-1H-Indole 4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine 4-Fluoro-2-Iodoaniline 4-Fluoro-2-Nitroaniline 4-Fluoroaniline 4-Fluorobenzaldehyde 4-Fluorobenzamide 4-Fluorobenzenesulfonyl Chloride 4-Fluorobenzo[D]Thiazole 4-Fluorobenzoic Acid 4-Fluorobenzonitrile 4-Fluoroisoquinoline 4-Fluorophenol 4-Fluoropyrimidine 5-Fluoro-1,2,3,4-Tetrahydroisoquinoline 5-Fluoro-1H-Benzo[D][1,2,3]Triazole 5-Fluoro-1H-Benzo[D]Imidazole 5-Fluoro-1H-Indole 5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine 5-Fluoro-2,3-Dihydro-1H-Indene 5-Fluoro-2,3-Dihydrobenzofuran 5-Fluoro-2-Methylpyridine 5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 5-Fluorochromane 5-Fluoroindoline 5-Fluoroisoindolin-1-One 5-Fluoropyridin-2-Amine 5-Fluoropyrimidine 6-Fluoro-1,2,3,4-Tetrahydroisoquinoline 6-Fluoro-1,2,3,4-Tetrahydroquinoline 6-Fluoro-1H-Indazole 6-Fluoro-1H-Indole 6-Fluoro-1H-Pyrrolo[2,3-B]Pyridine 6-Fluorobenzo[D]Thiazole 6-Fluorochromane 6-Fluoropyridin-2-Amine 6-Fluoropyridin-3-Amine 7-Fluoro-1,2,3,4-Tetrahydroisoquinoline 7-Fluoro-1,2,3,4-Tetrahydroquinoline 7-Fluoro-1H-Indazole 7-Fluoro-1H-Indole 7-Fluorobenzo[D]Thiazole 7-Fluoroindoline-2,3-Dione 7-Fluoroisoquinoline 8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 8-Fluorochromane 8-Fluoroimidazo[1,2-A]Pyridine 8-Fluoroisoquinoline 8-Fluoroquinazoline Benzenesulfonyl Fluoride Ethyl 2-Fluorobenzoate Ethyl 3-Fluorobenzoate Fluorobenzene Methyl 2,6-Difluorobenzoate Methyl 2-Fluorobenzoate Methyl 3-Fluorobenzoate Methyl 4-Fluorobenzoate Methyl 6-Fluoronicotinate N-(3-Fluorophenyl)Acetamide N-(4-Fluorophenyl)Benzamide Pentafluoro(Phenyl)-L6-Sulfane Phenyl Trifluoromethanesulfonate Tert-Butyl (4-Fluorophenyl)Carbamate Trifluoro(Phenyl)Borate

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1,1-Difluoroethyl 2,2-Difluoroacetic Acid 2,2-Difluoroethoxy 2,2-Difluoroethyl 2-Bromo-1,1,2,2-Tetrafluoroethoxy 2-Fluoroethyl Bromo-Fluorobenzene Carbonyl Fluoride Chloro-Fluoro-Benzene Dichlorofluorobenzene Difluoro Difluoroaniline Difluorobenzaldehyde Difluorobenzamide Difluorobenzenesulfonamide Difluorobenzoate Difluorobenzylamine Difluorocyclobutanecarboxylate Difluoroethyl Difluoroethyl Difluoromethoxy Difluoromethoxy Difluoropiperidine Difluoropropan Difluoropropan Difluoropyrimidine Difluoroquinoline Ethyl 2,2-Difluoro-Acetate Fluindamine Fluindenamine Fluoro-Benzenesulfonyl-Chloride Fluoro-Benzoimidazole Fluoro-Dihydro-Benzoxazine Fluoro-Indazol-Amine Fluoro-Indazole-Carboxylate Fluoro-Indole-Carboxylate Fluoro-Methyl Fluoro-Methyl-Indazole Fluoro-Naphthyridine Fluoro-Phenyl-Boronic Acid Fluoro-Pyrrolopyridine Fluoroacetanilide Fluoroacetophenone Fluoroaniline Fluoroanisole Fluorobenzaldehyde Fluorobenzamide Fluorobenzenesulfonamide Fluorobenzenethiol Fluorobenzimidamide Fluorobenzo Fluorobenzoate Fluorobenzoic Fluorobenzoyl Fluorobenzoyl-Chloride Fluorobenzylamine Fluorobromobenzene Fluorocarboxylic Acid Fluorochroman Fluorocinnamic Fluorocinnamic Fluorocinnamic Acid Fluorocyclopropanecarboxylic Fluoroethoxy Fluoroethyl Fluoroethyl Fluoroimidazo Fluoroindan Fluoroindan Fluoroisonicotinaldehyde Fluoroisonicotinate Fluoroisonicotinic Fluoroisonicotinic Acid Fluoromethyl Fluoromethyl Fluoromethyl-Indole Fluoronicotinaldehyde Fluoronicotinamide Fluoronicotinate Fluoronicotinic Fluoronicotinic Fluoronicotinic Acid Fluoronitrobenzene Fluorophenyl Fluorophenyl-Borate Fluorophenyl-Boronate Fluorophenylisocyanate Fluorophenylisothiocyanate Fluoropropan Fluoropropan Fluoropyrimidine Fluoroquinazoline Fluoroquinoline Fluorostyryl Fluorosulfonyl Fluorosulfonyl Fluorotoluene Heptadecafluorodecyl Heptafluoro Hexafluoro Hexafluoro Hexafluoropropan Hexafluoropropan Nonafluoro Nonafluoro Nonafluorobutane Nonafluorobutane Nonafluorohexyl Nonafluorohexyl Octafluoro Octafluoro Pentafluoro Pentafluorobenzoate Perfluorohexyl Perfluorohexyl Tetrafluoro Tetrafluoro Tetrafluoroaniline Tetrafluoroethoxy Tetrafluoroethoxy Tetrafluoropropyl Tetrafluoropropyl Tetrahydroquinoline-Fluoro Tridecafluorooctyl Tridecafluorooctyl Trifluoro Trifluoro Trifluoroacetamide Trifluoroacetyl Trifluoroaniline Trifluorobenzaldehyde Trifluorobenzoate Trifluorobenzoylchloride Trifluorobut Trifluorobut Trifluorobutane Trifluorobutane Trifluoroethan Trifluoroethan Trifluoroethanamine Trifluoroethanol Trifluoroethoxy Trifluoroethoxy Trifluoroethyl Trifluoromethanesulfonamide Trifluoromethanesulfonyl Trifluoromethoxy Trifluoromethoxy Trifluoromethylthio Trifluoromethylthio Trifluoropropane Trifluoropropanoate Trifluoropropyl

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    2,5-Difluoro-4-methylbenzoic acid

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    5-Bromo-2-fluoro-4-methylbenzoic acid

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