Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1-Fluoro-3-Methylbenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CH3).
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Alkylation: Similar to acylation, toluene can also undergo Friedel-Crafts alkylation reactions, where an alkyl group is introduced onto the benzene ring. Alkylation reactions also require a Lewis acid catalyst.
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Methyl 2-fluoro-5-hydroxy-4-methylbenzoate
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Methyl 5-amino-2-fluoro-4-methylbenzoate
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(2-Fluoro-5-methoxy-4-methylphenyl)boronic acid
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(4,5-Difluoro-2-methylphenyl)boronic acid
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(4-Fluoro-5-formyl-2-methylphenyl)boronic acid
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(3-Fluoro-5-methylphenyl)methanamine hydrochloride
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