Home Chemistry Heterocyclic Building Blocks Acridines Acridine
Electrophilic Aromatic Substitution: Acridine can undergo electrophilic aromatic substitution reactions. For example, it can react with nitric acid (HNO3) to form acridine N-oxide or with acylating agents to introduce acyl groups onto the nitrogen atoms.
Reduction: Acridine can be reduced to form 9,10-dihydroacridine by hydrogenation or other reducing agents.
Halogenation: Acridine can undergo halogenation reactions, where halogen atoms (e.g., chlorine or bromine) can replace hydrogen atoms on the benzene rings.
Ring Cleavage: Acridine can be cleaved at various positions to yield different products. For example, it can be cleaved to form 9-aminofluorene and 3-aminophenanthrene through ring-opening reactions.
Oxidation: Acridine can be oxidized to form acridine-N-oxide or other oxidation products, depending on the oxidizing agent used.
Photochemical Reactions: Acridine can undergo photochemical reactions, including photochemical isomerization and photodimerization.
Coordination Chemistry: Acridine and its derivatives can serve as ligands in coordination complexes with transition metal ions.
Biological Reactions: Acridine derivatives have been used in medicinal chemistry for their anticancer and antibacterial properties, and they can interact with DNA through intercalation.
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