Home Chemistry Heterocyclic Building Blocks Pyridines (2-Chloropyridin-4-Yl)Boronic Acid
Suzuki-Miyaura coupling: In this reaction, the (2-chloropyridin-4-yl)boronic acid reacts with an aryl or vinyl halide in the presence of a palladium catalyst and a base to form a new carbon-carbon bond. This reaction is widely used for the synthesis of biaryls and heteroaryls.
Boronic acid protection: The boronic acid group in (2-chloropyridin-4-yl)boronic acid can be protected with various protecting groups, such as pinacol or methyl groups, to prevent unwanted reactions or to enhance the reactivity of the boronic acid moiety.
Boronate ester formation: (2-chloropyridin-4-yl)boronic acid can react with alcohols in the presence of a base to form boronate esters. This reaction is useful for the introduction of boronic acid functionality into molecules that lack it.
Oxidation reactions: The boron atom in (2-chloropyridin-4-yl)boronic acid can undergo oxidation to form boronic acid derivatives with higher oxidation states, such as boronic acid pinacol esters or boronic acid diesters.
Hydrolysis: Under acidic or basic conditions, the boronic acid group can undergo hydrolysis to form the corresponding boronic acid or boronic acid salts.
Boronic acid hydrolysis: Boronic acids can undergo hydrolysis reactions in the presence of water or aqueous acid to form the corresponding boronic acid derivatives, such as boronic acid diols.
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(3-Bromo-2-chloropyridin-4-yl)boronic acid
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(2-Chloro-6-(trifluoromethyl)pyridin-4-yl)boronic acid
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(2-Chloro-5-(trifluoromethyl)pyridin-4-yl)boronic acid
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(2-Chloro-5-methoxypyridin-4-yl)boronic acid
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