Chemistry Heterocyclic Building Blocks Triazines 1,2,4-Triazine

1,2,4-Triazine

Electrophilic Substitution: 1,2,4-triazine can undergo electrophilic aromatic substitution reactions, similar to benzene and other aromatic compounds. In these reactions, an electrophile (a species that seeks electrons) replaces a hydrogen atom on the ring. For example, nitration (addition of a nitro group, NO2) and halogenation (addition of a halogen atom, such as Cl or Br) are common electrophilic substitutions. Nucleophilic Addition: 1,2,4-triazine can react with nucleophiles, such as amines or organometallic compounds, at its nitrogen atoms. This can result in the formation of substituted 1,2,4-triazine derivatives. Reduction: 1,2,4-triazine can be reduced to form corresponding hydrazine derivatives using reducing agents like sodium borohydride (NaBH4) or hydrogen gas H2 in the presence of a catalyst. Alkylation and Acylation: 1,2,4-triazine can undergo alkylation (addition of alkyl groups) and acylation (addition of acyl groups) reactions at its nitrogen atoms or on the aromatic ring. These reactions are often carried out in the presence of appropriate alkylating or acylating agents. Ring Cleavage: Under certain conditions, 1,2,4-triazine can undergo ring cleavage reactions, leading to the formation of simpler compounds. For example, cleavage of the triazine ring can result in the formation of amines and other nitrogen-containing compounds. Oxidation: 1,2,4-triazine can be oxidized to form various oxidation products, depending on the reaction conditions and the choice of oxidizing agents. Metal Complexation: 1,2,4-triazine derivatives can form complexes with various metal ions, leading to the formation of coordination compounds.

Further Reading:

Framework+−

1,2,4-Triazine 1,3,5-Triazin-2-Amine 2,4,6-Triphenoxy-1,3,5-Triazine 2,4,6-Triphenyl-1,3,5-Triazine 2,4-Diphenyl-1,3,5-Triazine 2-Chloro-1,3,5-Triazine 2-Methoxy-1,3,5-Triazine 2-Phenyl-1,3,5-Triazine N2,N4,N6-Triphenyl-1,3,5-Triazine-2,4,6-Triamine Pyrrolo[2,1-F][1,2,4]Triazine

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Amino-Triazine Benzotriazine Methyl-Triazine Other-Triazine Phenyl-Triazine Pyrazolotriazine Pyridyl-Triazine Triazin-Amine Triazine-One

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Aromatic Heterocycles Imidazoles Morpholines Other Aliphatic Heterocycles Pyridines

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Alcohols Alkenyls Amides Amines Aryls Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Ethers Fluorinated Building Blocks Hydrazines Phenols Sulfides Trifluoromethyls

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