Home Chemistry Heterocyclic Building Blocks Oxazolines 2-Phenyl-4,5-Dihydrooxazole
Ring Opening: The oxazole ring can undergo ring-opening reactions under certain conditions. This can occur through cleavage of one of the carbon-oxygen bonds in the ring, resulting in the formation of open-chain compounds.
Acylation: 2-Phenyl-4,5-dihydrooxazole can undergo acylation reactions, where acyl groups (RCO-) are introduced to the molecule. For example, treatment with acyl chlorides in the presence of a base can lead to the formation of acylated derivatives.
Alkylation: Alkylation reactions involve the introduction of alkyl groups (R-) to the molecule. This can be achieved by treating the compound with alkyl halides or other alkylating agents in the presence of a base.
Dehydration: Under suitable conditions, 2-phenyl-4,5-dihydrooxazole can undergo dehydration reactions, resulting in the removal of water to form a different compound.
Reduction: The oxazole ring or other functional groups within the molecule can be reduced to yield saturated compounds. Common reducing agents include metal hydrides like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: Oxidation reactions can be employed to convert 2-phenyl-4,5-dihydrooxazole to more highly oxidized derivatives. Common oxidizing agents include potassium permanganate (KMnO4) and chromic acid (H2CrO4).
Nucleophilic Substitution: If there are electrophilic sites in the molecule, it can undergo nucleophilic substitution reactions. Nucleophiles can attack and replace certain functional groups.
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(S)-2-(2-Bromophenyl)-4-(tert-butyl)-4,5-dihydrooxazole
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(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol
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(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol
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(S)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol
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(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol
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2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol
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(R)-4-Isopropyl-2-(2-(methylthio)phenyl)-4,5-dihydrooxazole
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2-(2-Methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole
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(S)-2-(2-Bromophenyl)-4-isopropyl-4,5-dihydrooxazole
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(R)-2-(2-Bromophenyl)-4-isopropyl-4,5-dihydrooxazole
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(S)-N-(2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide
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