Growth Hormone Secretagogue Receptor (GHSR) is a member of the G protein-coupled receptor family, primarily existing in two subtypes, GHSR1a and GHSR1b. GHSR1a is expressed in various tissues such as the brain, stomach, and pancreas. It serves as the main receptor for Growth Hormone Secretagogues (GHS) and the hunger hormone ghrelin, regulating appetite, energy balance, and growth hormone release. Activation of GHSR1a initiates multiple signaling pathways, including cAMP and Ca²⁺ signals, influencing appetite, fat metabolism, and insulin secretion. Gene-specific expression and mutations are associated with diseases like obesity, growth disorders, and metabolic syndrome.