Home Chemistry Heterocyclic Building Blocks Quinolines 1-Cyclopropyl-3-(4-(Quinolin-4-Yloxy)Phenyl)Urea
Acylation: You can react it with acyl chlorides or anhydrides to form amides, replacing the urea group. For example, reaction with acyl chloride would yield 1-cyclopropyl-3-(4-(quinolin-4-yloxy)phenyl)-N-acylurea.
Reduction: The cyclopropyl ring can be reduced using reducing agents like lithium aluminum hydride (LiAlH4) to form 1-cyclopropyl-3-(4-(quinolin-4-yloxy)phenyl)amine.
Alkylation/Arylation: You can react it with alkyl halides or aryl halides in the presence of a base to introduce alkyl or aryl groups onto the urea nitrogen, replacing the cyclopropyl group.
Heterocycle Formation: The quinoline group can participate in various reactions to form fused heterocyclic compounds. For example, it can be used in a Pictet-Spengler reaction to form tetrahydroquinolines.
Hydrolysis: Under acidic or basic conditions, the urea group can undergo hydrolysis to form 1-cyclopropyl-3-(4-(quinolin-4-yloxy)phenyl)amine and carbon dioxide.
Oxidation: Oxidizing agents can be used to oxidize the compound, potentially converting it into compounds with oxidized functional groups.
Substitution Reactions: The phenyl group attached to the urea nitrogen can undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, or Friedel-Crafts reactions.
Cyclization: Depending on reaction conditions and reagents, it may undergo cyclization reactions, forming various cyclic compounds.
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4-(4-(3-Cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide
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4-(3-Chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxylic acid
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