Home Chemistry Heterocyclic Building Blocks Pyrazines 2-Phenylpyrazine
Arylation or Alkylation: 2-phenylpyrazine can undergo electrophilic aromatic substitution reactions, where the phenyl ring can be further substituted with other aryl or alkyl groups. This can be achieved by reacting it with appropriate reagents and catalysts.
Nitration: Nitration of the phenyl ring can be carried out by reacting 2-phenylpyrazine with a mixture of concentrated nitric acid (HNO3) and sulfuric acid (H2SO4). This can introduce a nitro group (-NO2) onto the phenyl ring.
Reduction: Reduction reactions can be used to convert functional groups on the pyrazine ring or phenyl ring. For example, the nitro group can be reduced to an amino group (-NH2) using reducing agents like hydrogen gas H2 and a catalyst, such as palladium on carbon (Pd/C).
Oxidation: Oxidation reactions can be employed to convert certain functional groups to other functional groups. For instance, oxidation of a primary alcohol on the phenyl ring can lead to the formation of a carboxylic acid group (-COOH).
Substitution Reactions: The nitrogen atoms in the pyrazine ring can participate in various substitution reactions, leading to the introduction of different functional groups on the pyrazine ring.
Cyclization Reactions: Depending on the reaction conditions and reagents, 2-phenylpyrazine can undergo cyclization reactions, forming other heterocyclic compounds.
Cross-Coupling Reactions: 2-phenylpyrazine can be used in cross-coupling reactions, where it is coupled with other organic compounds using transition metal catalysts to form new carbon-carbon or carbon-heteroatom bonds.
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6-(4-(Trifluoromethyl)phenyl)pyrazin-2-amine
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